Treatment of cononavirus(COVID-19)

Treatment of coronavirus infection


Health specialists in India have been successful in treating coronavirus. combination of drugs Lopinvir, oseltamivir with chlorphenamine.

The anti-viral drug Favilavir has secured approval from the National Medical Products Administration of China to treat coronavirus infection Covid-19, according to media reports.

According to the report of China Daily, the Taizhou government in Zhejiang province announced the approval, which marks the authorization of the first drug against the new coronavirus infection.

Favilavir allegedly has shown the efficacy with very little side effects in an ongoing 70-patient clinical trial in Shenzhen, Guangdong province. The drug’s generic version received the approval.

Production of this anti-viral drug will begin soon as per the news agency.

Among all the upper respiratory disorders, only Coronavirus causes up to one-third of community-acquired upper respiratory tract infections in adults and probably also play a role in severe respiratory infections in both children and adults. Besides, certain coronaviruses may cause diarrhea in infants and children.


The symptoms of COVID-19

The symptoms of COVID-19, coronavirus infection symptoms,
symptoms are seen after coronavirus infection


The WHO described the symptoms of 55,924 laboratory-confirmed cases of COVID-19 in China in the period up to February 20.
The visualization here shows this data.

The most common symptoms which are seen after the infection of coronavirus infection


It is most crucial to know the common symptoms: fever and a dry cough.

As the investigation shows, close to 90% of infected patients had a fever and two-thirds had a dry cough.

The third most common symptom was fatigue. Almost 40% of cases suffered from it.
‘Sputum production’ was experienced by every third person. Sputum is not saliva. It is a thick mucus that is coughed up from the lungs.

Of the 55,924 cases, fewer than 1-in-5 (18.6%) experienced shortness of breath (‘dyspnoea’).

A case study on infected patients reported that a much higher share (55%) of cases suffered from dyspnoea, but this was based on a much smaller number of cases (835 patients).

Among the infected patient from deadly coronavirus most common symptoms are shared with those of the common flu or cold. So it is also good to know which common symptoms of the common flu or the common cold are not symptoms of COVID-19. COVID-19 infection seems to rarely cause a runny nose.

The wrong facts about COVID-19 are circulating online, including many fake cures or treatments for the disease.

Almost seven companies sell the product by saying it can cure coronavirus infection have been warned by the Food and Drug Administration for fraudulent products to treat COVID-19. The products cited in these warning letters include teas, essential oils, tinctures, and colloidal silver.



However, coronavirus infection increases in the case of:


  •  6% in people with high blood pressure
  •  6% in people with long-term lung problems such as those caused by a lifetime of smoking
  •  7% in people with diabetes
  •  11% in people with cardiovascular disease

coronavirus infection and health condition, COVID-19
coronavirus infection and health condition


What is being done to find an effective treatment?


Vaccines and treatment options for COVID-19 are currently being investigated around the world. There’s some evidence that certain medications may have the potential to be effective about preventing illness or treating the symptoms of COVID-19.

Researchers are performing randomized controlled trials. After evaluating the results in humans. The potential vaccines and other treatments will become available for the citizen. This may take several months or longer.

Here are some treatment options that are currently being investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms.


Remdesivir


Remdesivir is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases.

These studies add further evidence that Remdesivir can help in the treatment and prophylaxis of emerging COVID-19, which is showing signs of being perhaps a less fatal but more contagious CoV compared with its recent predecessors as it spreads worldwide

Why Remdesivir is used in the treatment for coronavirus infection(COVID-19)?


It is an experimental antiviral drug that was designed to target Ebola. Virologists have found that Remdesivir is highly effective at fighting the novel coronavirus in isolated cells. 


Due to its effectiveness of Remdesivir, the production of an experimental drug has become a focal point for the hopes of an effective treatment for coronavirus infection in the united states.

China and Italy are already using Remdesivir on a compassionate basis to treat small numbers of patients with severe Covid-19

The drug is being evaluated in multiple trials, the first two of which began recruiting patients in China in early February and another is enrolling patients in the US.

The action of Remdesivir is it attacks the virus’s ability to replicate in the body of animals. It could potentially help make people’s disease less severe, save lives for those hospitalized, and be used prophylactically for hospital workers and perhaps even in the community to limit spread out there.


Several trials have undergone in the lower mammals but this treatment is not yet approved as a proper treatment for humans, but two clinical trials for this drug have been implemented in China. One clinical trial was recently also approved by the FDA in the United States.


Chloroquine in treatment of Covid-19


Chloroquine is the medicine that’s used to fight malaria, amebiosis and autoimmune diseases. It’s been in use for more than 70 years trusted Source and is considered safe.

Before using chloroquine, tell your doctor if you have ever had


  • cardiovascular disease, heart rhythm disorder (such as long QT syndrome)
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood)
  • psoriasis
  • porphyria
  • liver or kidney disease
  • alcoholism
  • epilepsy or other seizure disorder
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency; or
  • problems with your vision or hearing

What should we avoid while taking chloroquine as a treatment for COVID-19(coronavirus infection)?



Avoid taking an antacid or Kaopectate (kaolin-pectin) within 4 hours before or after you take chloroquine. Some antacids can make it harder for your body to absorb chloroquine.


If you also take an antibiotic called ampicillin, avoid taking it within 2 hours before or 2 hours after you take chloroquine. Chloroquine can make ampicillin much less effective when taken at the same time.


Side effects of Chloroquine


Signs of an allergic reaction (difficulties in breathing, swelling in your face or throat) 

Severe skin reaction (fever, sore throat, eye burn, skin itchiness, a red or purple skin rash that spreads and causes blistering and peeling).

NOTE: Taking chloroquine long-term or at high doses may cause irreversible damage to the retina of your eye

Researchers have discovered that this drug is effective at fighting the SARS-CoV-2 virus in studies done in the lab.
At least 10 clinical trials trusted Source is currently looking at the potential use of chloroquine as an option for combating the novel coronavirus.


Lopinavir and ritonavir as a treatment for COVID-19


The combination of Lopinavir and ritonavir are popularly known as Kaletra which is designed to treat HIV. It helps to decrease the amount of HIV in your body so your immune system can work better.

According to the World Health Organization (WHO), there could be benefits to using Kaletra in combination with other drugs.

Effectiveness of using Kaletra

This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Both lopinavir and ritonavir belong to a class of drugs known as HIV protease inhibitors.

In South Korea, a 54-year-old man was given a combination of these two drugs and had a significant reduction in the symptoms of coronavirus infection.

Bad effect of using Kaletra

Kaletra can make birth control pills or patches less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Kaletra.

Before using Kaletra(Lopinavir and ritonavir), tell your doctor if you have ever had

  • liver disease (hepatitis B or C)
  • cardiovascular disease, heart rhythm disorder, or a family history of long QT syndrome
  • pancreas problems
  • diabetes
  • low levels of potassium in your blood or
  • a bleeding disorder such as hemophilia

At what health conditions we should stop using Kaletra as a treatment drug for coronavirus infection

  • headache with chest pain and severe dizziness, fainting, increased heartbeat

  • severe pain in your upper stomach radiating to your back, nausea, and vomiting

  • liver problems--loss of appetite, stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

  • high blood sugar--increased thirst, increased urination(showing symptoms of diabetes)

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, eye burn, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.


Chlorphenamine


Chlorphenamine is a drowsy (sedating) antihistamine. It's more likely to make you feel sleepy than some other antihistamines.

It's mainly used for:

  • hay fever
  • red, itchy eyes (conjunctivitis)
  • eczema
  • urticaria caused by food allergies 
  • insect bites and stings

Common side effects:

  • feeling sick (nausea)
  • sleepy or dizzy
  • you may also have difficulty concentrating
  • dry mouth
  • headache
  • blurred vision.

APN01


A clinical trial is set to start soon in China to examine the potential of a drug called APN01 to fight the novel coronavirus.


The scientists who first developed APN01 in the early 2000s discovered that a certain protein called ACE2 is involved in SARS infections. This protein also helped protect the lungs from injury due to respiratory distress.


From recent research, it turns out that the 2019 coronavirus, like SARS, also uses the ACE2 protein to infect cells in humans.
The randomized, dual-arm trial will look at the effect of the medication on 24 patients for 1 week.

Half of the participants in the trial will receive the APN01 drug, and the other half will be given a placebo. If results are encouraging, larger clinical trials will be done.

The APN01 drug candidate builds on a previous discovery that ACE2 protein is the key receptor for the SARS virus, as well as to protect the lung.

APN01 will be assessed for its ability to improve outcomes in Covid-19 patients with a serious infection in the new randomized, dual-arm trial in China.

“First, APN01 keeps the virus from infecting cells, and second, it should prevent lung failure and multiple organ complications, the source of most of the mortality we are seeing with COVID-19.”


The primary aim of the trial is to assess whether APN01 could decrease the SARS-CoV-2 virus viral load, along with the number of days patients suffer from fever.

VIENNA, Austria I February 26, 2020, I APEIRON Biologics AG, a biotechnology company with an approved product on the market as well as a broad preclinical and clinical pipeline, today announced the launch of a Pilot investigator-initiated clinical trial (IIT) with APN01, a recombinant human angiotensin-converting enzyme 2 (rhACE2), to treat patients with severe coronavirus infection in the People's Republic of China.

About APN01

APN01 is a recombinant human Angiotensin-Converting Enzyme 2 (rhACE2) and was developed by APEIRON for the treatment of acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary arterial hypertension (PAH).

After licensing from APEIRON in February 2010, GSK conducted trails from 2014 to 2017 to treat acute lung injury, acute respiratory distress syndrome and pulmonary arterial hypertension, the latter being the major source of Covid-2019 mortalities, the disease caused by the new coronavirus 2019-nCoV. 

Favilavir


China has approved the use of the antiviral drug Favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat.


Although the results of the study haven’t been released yet, the drug has supposedly shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people.

The National Medical Products Administration of China has approved the use of Favilavir, an anti-viral drug, as a treatment for coronavirus. The drug has reportedly shown efficacy in treating the disease with minimal side effects in a clinical trial.
Treatment of cononavirus(COVID-19) Treatment of cononavirus(COVID-19) Reviewed by OMNIT ARYAN MAURYA on 18 March Rating: 5

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